Medically the evaluation by Darren Hein, PharmD — created by college of Illinois — update on September 2, 2018


Mucinex and also Nyquil Cold & Flu are two common, over-the-counter remedies you can find on your pharmacist’s shelf. Compare the symptoms that each medicine treats as well as their side effects, interactions, and warnings to see if one is a far better option because that you.

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The key differences in between these drugs space their energetic ingredients and also how those job-related to treat your symptoms.

Mucinex treats chest congestion. The main energetic ingredient is one expectorant called guaifenesin. It functions by thinning the consistency of mucus in her air passages. This i m going up mucus in her chest for this reason you can cough it up and also out.

NyQuil temporary treats typical cold and flu symptom such together fever, cough, sleep congestion, young aches and pains, headache, and runny nose and sneezing. The energetic ingredients are acetaminophen, dextromethorphan, and doxylamine. These ingredients each job-related a small differently.

For example, acetaminophen is a pain reliever and also fever reducer. It transforms the means your body senses pain and regulates temperature. Dextromethorphan suppresses the signals in your brain that trigger your coughing reflex. Doxylamine, top top the other hand, block a substance in her body referred to as histamine. This substance causes allergy symptom such as itchy, watery eyes, runny nose, and also itchy sleep or throat. Together, this ingredients carry out the relief girlfriend can gain from NyQuil.

The following table summarizes the differences between Mucinex and NyQuil at a glance.

Active ingredient(s)guaifenesinacetaminophen, dextromethorphan, doxylamine
Symptom(s) treatedchest congestionfever, cough, nasal congestion, young aches and pains, headache, sore throat, runny nose, sneezing
Usagethroughout the dayat night
Formsextended-release dental tablet*, dental granulesoral fluid capsule, oral solution
Risk that interactionsnoyes
Risk of significant side effectsnoyes

*There is likewise an extra-strength form of this tablet, which includes twice as much of the active ingredient.

Forms and dosage

You can use Mucinex transparent the day, yet you frequently use NyQuil in ~ night to aid you sleep and let her body recover. The ingredient doxylamine in NyQuil also causes drowsiness to assist you gain rest.

Mucinex and NyQuil Cold & Flu are only for people 12 years and also older. However, NyQuil has other assets that are specifically made for kids ages 4 to 11 years.

The encourage dosage for each medicine varies according to the form. Monitor the recommended dosage on the package of whatever kind you choose. You will should ask your doctor for the exactly dosage the NyQuil to give to kids who space 4 come 11 years old.

Mucinex walk not have the risk of significant side effects. However, the complying with serious side results may be feasible with NyQuil:

vision problems, such as blurry visiondifficulty urinatingallergic reaction, with symptoms together as:red, peeling or blistering skinrashhivesitchingswelling that the face, throat, tongue, lips, eyes, hands, or lower legsdifficulty breath or swallowing

If you have serious next effects, you need to stop utilizing the drug and also call your doctor.


Drug interactions can increase or to decrease the effect of the various other medications. Interaction can additionally increase your danger of side effects. There space no known far-ranging interactions v guaifenesin, the active ingredient in Mucinex. However, every three active ingredients the NyQuil interact with other drugs.

Acetaminophen can connect with:

warfarinisoniazidcarbamazepine (Tegretol)phenobarbitalphenytoin (Dilantin)phenothiazines

Dextromethorphan can connect with:

isocarboxazidphenelzine (Nardil)selegilinetranylcypromine (Parnate)

Doxylamine can connect with:

isocarboxazidphenelzine selegilinetranylcyprominelinezolidopioids such together fentanyl, hydrocodone, methadone, and also morphine

You shouldn’t usage Mucinex or NyQuil come treat a permanent cough. Using too much can reason harmful effects. You also shouldn’t usage these assets to treat symptom of any type of medical condition you have without talking to your medical professional first.

Other conditions

Other conditions you may have can influence how NyQuil works for you. In part conditions, this drug deserve to be harmful. Asking a doctor before using NyQuil if you have:

liver diseaseglaucomaurinating because of enlarged prostate gland


Don’t use Mucinex or NyQuil for much longer than seven days. If her symptoms no relieved ~ a week, contact your doctor and also stop using these drugs.

NyQuil has acetaminophen, which have the right to cause far-ranging liver damage if friend overuse it. Taking an ext than 4 doses of NyQuil in 24 hours can cause severe liver damage. Numerous over-the-counter drugs also contain acetaminophen. If you take NyQuil, make sure you don’t take it it with various other drugs the contain acetaminophen. This will help make certain you nothing accidentally usage too lot of the drug.

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Mucinex and also NyQuil are both commodities that relax symptoms of the typical cold or flu. The symptoms they treat space different. You deserve to take Mucinex and NyQuil together safely if you monitor the recommended dosage for each drug. However, acquisition Mucinex at night with NyQuil could actually keep you native falling asleep. Mucinex will loosen your mucus, which can reason you to wake up to cough.

Deciding between the two might simply mean selecting the drug that treats the symptom that room bothering friend the most. That course, you should never take any drug if you’re no sure exactly how to usage it or if it’s appropriate for you. Always talk come your physician if you have questions.